Treatment of autoimmune encephalitis： Transitioning from traditional approaches to a new era of precision medicine
10.19845/j.cnki.zfysjjbzz.2025.0093
- VernacularTitle:自身免疫性脑炎的治疗：由传统迈向精准新时代
- Author:
Yuxiu XIAO
1
;
Baojie WANG
1
;
Shougang GUO
1
Author Information
1. Department of Neurology，Shandong Provincial Hospital，Shandong University，Jinan 250021，China
- Publication Type:Journal Article
- Keywords:
Autoimmune encephalitis;
Targeted immunotherapy;
Monoclonal antibodies;
Chimeric antigen receptor T-cell immunotherapy
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(6):491-497
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune encephalitis（AE）is a group of inflammatory disorders within the central nervous system（CNS）triggered by autoimmune mechanisms. Most AE patients show good responses to first-line immunotherapies such as corticosteroids and intravenously injected immunoglobulin. Nevertheless，the adverse effects associated with extensive immunosuppression have become a difficult issue in treatment，and some patients with severe conditions or recurrence still require further intensive therapy. Therefore，it is urgently needed to search for novel treatment strategies with high efficiency，precision，and safety. In recent years，targeted immunotherapy and chimeric antigen receptor T-cell immunotherapy that specifically target immune cells or cytokines involved in the pathogenesis of AE have gradually become research hotspots，with good tolerability and safety，which provides new options for the clinical management of AE.
- Full text:2025071710041058314自身免疫性脑炎的治疗：由传统迈向精准新时代.pdf
