Outbreak of Posttransplant Lymphoproliferative Disorder (PTLD) in a Single Center.
- Author:
Chang Hwa LEE
1
;
Nak Won CHOI
;
Gheun Ho KIM
;
Chong Myung KANG
;
Oh Jeong KWON
Author Information
1. Department of Internal Medicine, Hanyang University Hospital, Seoul, Korea.kangjm@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Posttransplant lymphoproliferative disorder (PTLD), EBV, Transplantation
- MeSH:
Diagnosis;
Head;
Herpesvirus 4, Human;
Humans;
Immunosuppression;
Immunosuppressive Agents;
Incidence;
Kidney Transplantation;
Lymphoproliferative Disorders*;
Neck;
Risk Factors
- From:The Journal of the Korean Society for Transplantation
2004;18(2):188-193
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Post transplant lymphoproliferative disorder is a serious complication after renal transplantation. Although the precise etiology is unknown, the Ebstein-Bar virus and immunosuppressive agents appear to be risk factors. The presentation of PTLD is diverse. Many patients develop symptoms in head and neck, which make diagnosis difficult. We experienced 3 cases of PTLD successively one or three months apart during year 2002. Before 2002, PTLD was very rare in our center. The incidence of PTLD in renal transplants in our center is 0.7% (5 out of 752), which is similar to that of other reports. But the incidence is very high during year 2002. This seems to be intensified immunosuppression recently adopted. EBV monitoring is necessary for early detection of PTLD in renal transplants.
