Impact of carotid artery stenting on the progression of white matter hyperintensity volume in patients with carotid artery stenosis
10.19845/j.cnki.zfysjjbzz.2025.0083
- VernacularTitle:颈动脉支架植入术对颈动脉狭窄患者脑白质高信号体积进展的影响
- Author:
Jiawei YE
1
;
Yu GENG
2
Author Information
1. 杭州医学院基础医学与法医学院，浙江 杭州 310053
2. 浙江省人民医院 杭州医学院附属人民医院 神经内科，浙江 杭州 310014
- Publication Type:Journal Article
- Keywords:
Carotid artery stenosis;
Carotid artery stenting;
White matter hyperintensity
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(5):440-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether carotid artery stenting （CAS） is a protective factor against the progression of white matter hyperintensity （WMH） volume in patients with carotid artery stenosis. Methods A prospective study was conducted for the clinical， imaging， and follow-up data of patients with carotid artery stenosis who were treated in Zhejiang Provincial People's Hospital from January 2021 to June 2023. A total of 99 participants were included in this study， among whom 48 received CAS treatment （CAS group） and 51 did not receive CAS treatment （non-CAS group）. The two groups were analyzed in terms of baseline data and WMH volume during the 1-year follow-up. Results There were no significant differences in baseline data between the two groups （P>0.05）. There was no significant difference in overall WMH volume after follow-up between the two groups （P>0.05）， but compared with the non-CAS group， the CAS group showed a significantly lower degree of the progression of WMH volume within one year （-0.27 ml vs 2.82 ml， P<0.001）. There was a significant difference in the proportion of patients with new-onset stroke within one year between the CAS group and the non-CAS group （18.75% vs 37.25%， P=0.041）. The binary logistic regression analysis showed that CAS was an independent protective factor against the progression of WMH volume（OR=-0.37， 95%CI -0.78 to -0.03，P=0.046） and new-onset stroke within one year （OR=0.28， 95% CI 0.09 to 0.83， P=0.022）. Conclusion CAS is a protective factor against the progression of WMH volume and can effectively reduce the risk of stroke recurrence in patients with carotid artery stenosis.
- Full text:2025071708251120179颈动脉支架植入术对颈动脉狭窄患者脑白质高信号体积进展的影响.pdf
