Progress on the value of multi-target effect of Gouteng based on network pharmacology study
10.11665/j.issn.1000-5048.2024070502
- VernacularTitle:钩藤网络药理学多靶点效应价值研究进展
- Author:
Wenxin GAO
1
,
2
;
Chunxia GAO
;
Lingfei HAN
;
Wenyuan LIU
Author Information
1. 中国药科大学药物分析系, 南京 211198
2. 浙江省原料药安全研究中心(工艺技术创新平台), 杭州 310018
- Publication Type:Journal Article
- Keywords:
Uncaria rhynchophylla (Miq.)Miq. ex Havil;
network pharmacology;
alkaloid;
molecular mechanism;
neurological disorder;
cardiovascular disease
- From:
Journal of China Pharmaceutical University
2025;56(3):376-381
- CountryChina
- Language:Chinese
-
Abstract:
Uncaria rhynchophylla (Miq.)Miq. ex Havil (Gouteng) is a dry and hooked stem branch of Rubiaceae, which contains chemical components including alkaloids, terpenoids, flavonoids and organic acids. It has antioxidant, anti-inflammatory, and potential therapeutic effects on various diseases. The characteristics of network pharmacology are multi-component, multi-target and multi-channel, which can analyze the complex mechanism of the active ingredient group of traditional Chinese medicine and the disease markers, and clarify the relationship between drugs, targets and diseases. This review summarises the research progress of the intervention of Gouteng in neurological disorders, cardiovascular diseases, inflammation, and other diseases based on network pharmacology and provides a theoretical foundation for the clinical application of Gouteng.
