Biological function of tRNA-derived small RNA and its expression and clinical significance in liver diseases
- VernacularTitle:转运RNA衍生小RNA（tsRNA）的生物学功能及在肝脏疾病中的表达和临床意义
- Author:
Yinli LI
1
;
Yan XU
1
;
Zhiwei GUAN
1
;
Lu MENG
1
;
Yitong QU
1
;
Jianli QIU
1
Author Information
- Publication Type:Review
- Keywords: MicroRNAs; Liver Diseases; Biomarkers
- From: Journal of Clinical Hepatology 2025;41(6):1227-1234
- CountryChina
- Language:Chinese
- Abstract: Liver diseases cannot be easily detected in the early stage， and although invasive diagnostic methods， such as liver biopsy， are relatively accurate， they tend to have a low degree of acceptance， which greatly limits the improvement in diagnosis and treatment techniques for liver diseases. Therefore， it is of great importance to search for new biomarkers and therapeutic targets. As an emerging biomarker for liquid biopsy， tRNA-derived small RNA （tsRNA） is abnormally expressed in various liver diseases including viral hepatitis， fatty liver disease， liver injury， and liver cancer， and it can affect the development and progression of liver diseases by regulating the biological functions such as gene expression， epigenetic regulation， and protein translation. This article reviews the origin， classification， and biological function of tsRNA， as well as the research advances in tsRNA as biomarkers and potential therapeutic targets for liver diseases， so as to provide ideas for the early diagnosis and treatment of liver diseases.
