Application value of gene-modified mesenchymal stem cells in liver diseases

VernacularTitle:基因修饰间充质干细胞在肝脏疾病治疗中的应用价值
Author: Tingting ZHAO ¹ ; Junfeng LI ¹ ; Dan ZHOU ² ; Xiaoqin GAO ² ; Wei YUE ³ ; Ruqin WANG ² ; Liting ZHANG ¹
Author Information

1. The First Clinical Medical College of Lanzhou University， Lanzhou 730000， China
2. Department of Hepatology & Infectious Diseases， The First Hospital of Lanzhou University， Lanzhou 730000， China
3. Department of Infectious Diseases， The First Hospital of Lanzhou University， Lanzhou 730000， China
Publication Type:Review
Keywords: Mesenchymal Stem Cells; Organisms， Genetically Modified; Liver Disease; Therapeutics
From: Journal of Clinical Hepatology 2025;41(6):1220-1226
CountryChina
Language:Chinese
Abstract: The immunomodulatory， repair， and regeneration-promoting functions of mesenchymal stem cells make them one of the potential treatment methods for liver diseases. At present， viral and non-viral delivery methods have been developed to genetically modify mesenchymal stem cells， and gene modification can promote the survival， homing， and cytokine secretion of mesenchymal stem cells， thereby enhancing the ability of mesenchymal stem cells to treat liver diseases. This article mainly summarizes the research advances in gene-modified mesenchymal stem cells in the treatment of liver diseases， in order to provide new insights and strategies for the clinical treatment of liver diseases.