Therapeutic effect of traditional Chinese medicine in liver cancer by regulating tumor-associated macrophages and its mechanism
- VernacularTitle:中药调控肿瘤相关巨噬细胞对肝细胞癌的治疗作用与机制
- Author:
Yi TANG
1
;
Guotai WANG
2
;
Yuhan JIANG
1
;
Chenyang WU
1
Author Information
- Publication Type:Review
- Keywords: Liver Neoplasms; Tumor-Associated Macrophages; Traditional Chinese Drugs
- From: Journal of Clinical Hepatology 2025;41(6):1199-1206
- CountryChina
- Language:Chinese
- Abstract: Liver cancer has high prevalence and mortality rates around the world， and its development and progression are closely associated with the interaction between the tumor microenvironment and tumor-associated macrophages （TAMs）. TAMs play a significant role in immune suppression， immune escape， cell proliferation， invasion， metastasis， and drug resistance in liver cancer. Traditional Chinese medicine （TCM）， with its unique therapeutic concepts and methods， has shown great potential in regulating TAMs and improving the prognosis of liver cancer. This article reviews the role and molecular mechanisms of TCM in regulating TAMs for the treatment of liver cancer， discusses the key role of TAMs in the progression of liver cancer， and analyzes the impact of Chinese medicinal components on the recruitment， polarization， and activity of TAMs and the expression of related factors based on TCM theory. Studies have shown that TCM can regulate the polarization state of TAMs， promote the formation of M1-type antitumor macrophages， and inhibit the activity of M2-type tumor macrophages， thereby playing a role in inhibiting the proliferation of liver cancer cells， promoting apoptosis， inhibiting angiogenesis， and enhancing immune response. In addition， this article also summarizes the molecular targets and mechanisms of action of TCM monomers， compound prescriptions， and novel preparations in the treatment of liver cancer， such as inhibiting the secretion of cytokines by TAMs， regulating signaling pathways， and affecting metabolic pathways， in order to provide a scientific basis for the application of TCM in liver cancer treatment and offer new ideas for immunotherapy for liver cancer.
