Role and clinical application prospect of epigenetics in lean nonalcoholic fatty liver disease
- VernacularTitle:表观遗传学在瘦型非酒精性脂肪性肝病中的作用及临床应用前景
- Author:
Junjiao XU
1
;
Sutong LIU
1
;
Qizhen ZHANG
1
;
Yajie GUAN
1
;
Beilei CUI
1
;
Wenjing WU
1
;
Minghao LIU
1
Author Information
- Publication Type:Review
- Keywords: Non-alcoholic Fatty Liver Disease; Epigenomics; Pathologic Processes
- From: Journal of Clinical Hepatology 2025;41(6):1161-1166
- CountryChina
- Language:Chinese
- Abstract: Epigenetic mechanisms play a crucial role in the development and progression of nonalcoholic fatty liver disease （NAFLD）， especially among lean individuals. The research on related epigenetic mechanisms has provided new clues and directions for revealing the underlying causes and treatment strategies of NAFLD. This article introduces the role of epigenetics in the development and progression of NAFLD among lean individuals in recent years， analyzes the latest research advances in the epigenetics of NAFLD in this population， and briefly describes the basic concepts of epigenetics， including DNA methylation， histone modifications， and non-coding RNA regulation. This article also discusses how epigenetic alterations impact the pathogenesis， disease progression， and treatment strategies of NAFLD in lean individuals.
