Balamuthia mandrillaris amoebic encephalitis： A case report and literature review
10.19845/j.cnki.zfysjjbzz.2025.0070
- VernacularTitle:狒狒巴拉姆希阿米巴脑炎1例报告并文献复习
- Author:
Yurong CHEN
1
,
2
;
Qishan ZHANG
1
,
2
Author Information
1. Department of Neurology，Chenzhou Hospital Affiliated to University of South China，Chenzhou First People&rsquo
2. s Hospital，Chenzhou 423000, China
- Publication Type:Journal Article
- Keywords:
Balamuthia mandrillaris;
Granulomatous amoebic encephalitis;
Infection;
Metagenomic next-generation sequencing
- MeSH:
Balamuthia mandrillaris
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(4):361-364
- CountryChina
- Language:Chinese
-
Abstract:
Infection of the human central nervous system by Balamuthia mandrillaris is very rare and is mostly observed in people engaged in agriculture-related occupations，with a high fatality rate. This article reports a case of Balamuthia mandrillaris amoebic encephalitis in southern Hunan, China，which was finally confirmed by metagenomic next-generation sequencing of cerebrospinal fluid. The patient gave up treatment and was discharged from the hospital without achieving remission after antiviral，anti-fungal，and anti-parasitic therapies，cranial pressure reduction，and symptomatic supportive treatment，and the patient died at 5 months after confirmed diagnosis. This article reviews related literature to improve the understanding of this disease among clinicians，and it is necessary to consider the possibility of this disease in case of encephalitis of unknown etiology. Early diagnosis and timely comprehensive anti-infective therapy should be performed to improve the success rate of treatment.
- Full text:2025071614485763988狒狒巴拉姆希阿米巴脑炎1例报告并文献复习.pdf
