Acute ischemic stroke associated with neurosyphilis comorbid with HIV infection： A case report and literature review
10.19845/j.cnki.zfysjjbzz.2025.0069
- VernacularTitle:神经梅毒合并HIV感染相关的急性缺血性卒中1例报告并文献复习
- Author:
Yuding LUO
1
,
2
;
Jian WANG
1
,
2
Author Information
1. 西南医科大学附属医院，四川 泸州 646000
2. 雅安市人民医院，四川 雅安 625000
- Publication Type:Journal Article
- Keywords:
Neurosyphilis;
Ischemic stroke;
Arteritis;
Middle cerebral artery occlusion;
High-resolution magnetic resonance imaging
- MeSH:
Neurosyphilis;
Arteritis
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(4):357-360
- CountryChina
- Language:Chinese
-
Abstract:
This article reports a male patient，aged 31 years，who were admitted due to sudden-onset speech and language impairment and limb weakness at the right side for more than 7 hours and achieved successful revascularization after endovascular treatment. Etiological screening revealed positive treponema pallidum particle agglutination （1∶1 280） and positive HIV antibodies in serum，as well as an increase in white blood cell count and positive TPPA （1∶640） in cerebrospinal fluid （CSF）. High-resolution magnetic resonance imaging of the vessel wall showed inflammatory changes in the vessel wall of the M1 segment of the left middle cerebral artery. After multidisciplinary consultation，the patient was diagnosed with acute ischemic stroke secondary to cerebral arteritis caused by neurosyphilis and HIV infection and was given antiplatelet therapy，benzathine penicillin for syphilis，and antiviral therapy. After 6 months of follow-up，the patient had a modified Rankin Scale score of 0 and achieved clearance of syphilis-related indicators in serum and CSF，and CT angiography confirmed revascularization without new-onset stenosis. The literature review shows that acute ischemic stroke is a common manifestation of co-infection with HIV and neurosyphilis in young individuals，and early syphilis detection in serum and CSF，HIV screening，and timely combination therapy are of great significance for improving prognosis.
- Full text:2025071614403595379神经梅毒合并HIV感染相关的急性缺血性卒中1例报告并文献复习.pdf
