Clinical features，recurrence risk，and long-term prognosis of anti-myelin oligodendrocyte glycoprotein-IgG associated disorders： An analysis of 91 cases
10.19845/j.cnki.zfysjjbzz.2025.0067
- VernacularTitle:91例MOGAD患者的临床特点及复发风险与长期预后评估
- Author:
Wenlin SUN
1
;
Nanchang XIE
1
Author Information
1. Department of Neurology，The First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052, China
- Publication Type:Journal Article
- Keywords:
Anti-myelin oligodendrocyte glycoprotein-IgG associated disorders;
Clinical features;
Cerebrospinal fluid;
Recurrence;
Prognosis
- MeSH:
Recurrence;
Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(4):341-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features and treatment of anti-myelin oligodendrocyte glycoprotein-IgG associated disorders （MOGAD） and the risk factors for recurrence and poor long-term prognosis. Methods A total of 91 patients who were diagnosed with MOGAD in The First Affiliated Hospital of Zhengzhou University from January 2018 to March 2023 were enrolled，and their clinical features and auxiliary examinations were analyzed，as well as the risk factors for recurrence and long-term prognosis. Results Among the 91 patients，69 experienced the first attack of MOGAD，and there were 39 female patients and 47 children （aged<18 years）. The proportion of patients with acute disseminated encephalomyelitis among children was significantly higher than that among adults （42.6% vs 18.2%，P=0.012），while the proportion of patients with transverse myelitis among adults was significantly higher than that among children （29.5% vs 2.1%，P<0.001）. The proportion of patients receiving hormones combined with immunoglobulins during hospitalization among children was significantly higher than that among adults （36.2% vs 11.4%，P=0.006），and the children had a significantly better Expanded Disability Status Scale （EDSS） score than the adults at discharge [1（0，1） vs 2（0，4.75），P=0.007]. Visual impairment was an independent risk factor for increased recurrence risk （OR=4.215，95%CI 1.236-14.377，P=0.022）. A higher EDSS score at discharge （OR=5.05，95%CI 1.27-20.07，P=0.021） and a higher number of attacks （OR=9.235，95%CI 1.352-63.10，P=0.023） were independent factors for poor long-term prognosis，while a steroid maintenance time of >5 weeks at initial diagnosis （OR=0.001，95%CI 0.00-0.33，P=0.001） was an independent factor for improving long-term prognosis. Conclusion For patients newly diagnosed with MOGAD，especially those with a high EDSS score at discharge and features indicating a high risk of recurrence （such as visual impairment），it is recommended that they receive an appropriate course of steroid maintenance treatment after acute-stage treatment.
- Full text:202507161417581824891例MOGAD患者的临床特点及复发风险与长期预后评估.pdf
