The pathophysiological role of zinc homeostasis in the development and progression of cerebral small vessel disease
10.19845/j.cnki.zfysjjbzz.2025.0057
- VernacularTitle:锌稳态在脑小血管病发生发展中病理生理的作用
- Author:
Le CAO
1
,
2
;
Wenzhao LIANG
3
Author Information
1. 吉林大学中日联谊医院神经内科，吉林 长春 130033
2. 吉林大学中日联谊医院呼吸与危重症医学科，吉林 长春 130033
3. 吉林大学中日联谊医院老年病全科医学科，吉林 长春 130033
- Publication Type:Journal Article
- Keywords:
Zinc homeostasis;
Cerebral small vessel disease;
Pathogenesis;
Nervous system disease;
Neurotoxicity
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral small vessel disease（CSVD） refers to a series of clinical， imaging， and pathological syndromes caused by various etiologies affecting arterioles，capillaries， and venules in the brain， and the main clinical manifestations of CSVD include cognitive impairment， gait and balance disorders， urinary incontinence， and mental and behavioral disorders such as depression， anxiety， apathy， and personality changes. At present， the pathophysiological mechanism of CSVD remains unclear. As one of the most important trace elements in the human body， zinc ions play an important role in the development of the nervous system， and the change in zinc ion concentration will affect a variety of nervous system diseases；therefore， the research on the association between zinc ion homeostasis and the development and progression of cSVD has gradually become a hot topic. This article reviews the mechanism of the development and progression of CSVD， the role of zinc ions in the nervous system， the association between zinc ions and the development and progression of CSVD， and the latest research advances.
- Full text:2025071613125975490锌稳态在脑小血管病发生发展中病理生理的作用.pdf
