Research advances in the role of O-GlcNAc glycosylation in ischemic stroke

VernacularTitle:O-GlcNAc糖基化修饰在缺血性脑卒中作用的研究进展
Author: Wenhua NING ^{1
,

2} ; Haiming WANG ^{1
,

2}
Author Information

1. 郑州大学第一附属医院康复医学科，河南郑州 450052
2. 河南省康复工程技术研究中心，河南郑州 450052
Publication Type:Journal Article
Keywords: Post-translational modification; Glycosylation; Ischemic stroke
MeSH: Glycosylation
From: Journal of Apoplexy and Nervous Diseases 2025;42(3):262-266
CountryChina
Language:Chinese
Abstract: O-GlcNAc glycosylation， as the most extensive type of glycosylation modification， is involved in the development and prognosis of ischemic stroke by regulating excitatory toxicity， mitochondrial function， synaptic plasticity， and immune metabolism and inhibiting endoplasmic reticulum stress and inflammatory response， and regulation of O-GlcNAc glycosylation is considered a promising therapeutic target for ischemic stroke.This article reviews the characteristics and specific mechanisms of O-GlcNAc glycosylation in ischemic stroke，in order to provide new ideas for the prevention and treatment of ischemic stroke.
Full text:2025071610414049368O-GlcNAc糖基化修饰在缺血性脑卒中作用的研究进展.pdf