Research progress of narcolepsy
10.19845/j.cnki.zfysjjbzz.2025.0043
- VernacularTitle:发作性睡病的研究进展
- Author:
Xuefeng XIANG
1
,
2
,
3
,
4
;
Hongju ZHANG
1
,
2
,
3
,
4
Author Information
1. Zhengzhou University People&rsquo
2. s Hospital &
3. Henan Provincial People&rsquo
4. s Hospital， Zhengzhou 450003， China
- Publication Type:Journal Article
- Keywords:
Narcolepsy;
Narcolepsy type1;
Hypocretin;
Human leucocyte antigen gene;
Cataplexy
- MeSH:
Narcolepsy;
Cataplexy
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(3):217-220
- CountryChina
- Language:Chinese
-
Abstract:
Narcolepsy（NP） is a rare central sleep disorder， and it is categorized into narcolepsy type1 （NT1） and narcolepsy type2（NT2）.The main clinical symptoms of NP include daytime lethargy， cataplexy induced by emotions， and sleep paralysis， with a peak onset during adolescence （with an age of 8‒12 years）. At present， the pathogenesis of NP remains unclear and is associated with various factors such as human leucocyte antigen （HLA）， infection， and epigenetic silencing， and the selective loss of hypocretin neurons in the hypothalamus is the key pathophysiological mechanism of NP. Pharmacological intervention is currently the main treatment method， and diagnostic delay can be as long as more than 10 years， which not only affects the social activities， academic performance， and work of patients， but also leads to mental health issues such as anxiety and depression. This article reviews the latest research findings in the epidemiology， pathogenesis， and treatment of NT1 and clarifies the deficiencies and controversies in current research， so as to provide new ideas and directions for subsequent studies.
- Full text:2025071609202565282发作性睡病的研究进展.pdf
