Charge shielding and targeted delivery strategies of cationic carriers
10.11665/j.issn.1000-5048.2024121201
- VernacularTitle:阳离子载体的电荷屏蔽和靶向递送策略
- Author:
Xinao LIU
1
,
2
;
Qinying CHEN
;
Dali CHEN
;
Jiasheng TU
;
Chunmeng SUN
Author Information
1. 中国药科大学药学院药用辅料及仿创药物研发评价中心, 南京210009
2. 国家药品监督管理局药物制剂及辅料研究与评价重点实验室, 南京210009
- Publication Type:Journal Article
- Keywords:
cationic carrier;
charge shielding;
stimuli-responsive;
smart delivery;
clinical translation
- From:
Journal of China Pharmaceutical University
2025;56(3):271-279
- CountryChina
- Language:Chinese
-
Abstract:
Cationic carriers have demonstrated broad application prospects in drug delivery due to their excellent drug-loading capacity and delivery performance. However, their high-density positive surface charge often leads to systemic toxicity and nonspecific uptake, posing significant barriers to clinical translation. In recent years, the emergence of charge shielding and stimuli-responsive strategies has provided effective avenues for modulating biocompatibility and targeting specificity. This review systematically summarizes the applications of chemical modification, natural polymer coating, and biomimetic membrane strategies in charge shielding. Furthermore, it explores the roles of endogenous stimuli such as pH, enzymes, and reactive oxygen species, as well as exogenous triggers like light and ultrasound, in achieving precise activation and controlled release. With the integration of multi-functional modules and the development of intelligent delivery platforms, cationic carriers are progressively advancing from laboratory research toward clinical translation. This review also discusses the translational potential and critical technical bottlenecks of related delivery systems, aiming to provide a theoretical framework and some reference for the design of next-generation smart delivery systems.
