Progress in pharmaceutical crystallographic study of mannitol
10.11665/j.issn.1000-5048.2024110401
- VernacularTitle:甘露醇的药物晶体学研究进展
- Author:
Huina LIU
1
,
2
;
Ke ZHANG
;
Yan MIAO
;
Yuanfeng WEI
;
Yuan GAO
Author Information
1. 中国药科大学中药学院, 南京 211198
2. 中国药科大学药学院, 南京 211198
- Publication Type:Journal Article
- Keywords:
mannitol;
polymorph;
cocrystal;
polymorphic transform;
pharmaceutical excipient
- From:
Journal of China Pharmaceutical University
2025;56(2):264-270
- CountryChina
- Language:Chinese
-
Abstract:
As a pharmaceutical excipient with low caloric value, low hygroscopicity, and high stability, mannitol is widely used in various dosage forms, such as solid, lyophilized and inhalation preparations, etc. It has different crystal structures (α, β and δ) and cocrystal, and the changes in the crystal structure will affect formulation properties of pharmaceutical formulations. This paper reviews structural features, physicochemical properties, and preparation methods of mannitol polymorphs and cocrystal formation, with emphasis on polymorphic transformation pathways, monitoring methods and the effect of polymorphic transformation on properties and application in pharmaceutical formulations, including tabletability, disintegration and dissolution properties. By systematically summarizing the crystallographic study of mannitol, this study attempts to provide new ideas for the development of novel pharmaceutical excipients and applications in pharmaceutical formulations.
