Causal association between immunophenotypes and the risk of ischemic stroke： A Mendelian randomization study
10.19845/j.cnki.zfysjjbzz.2025.0029
- VernacularTitle:免疫表型与缺血性卒中风险的因果关联：孟德尔随机化研究
- Author:
Xingzhu LI
1
,
2
;
Tong ZHANG
1
,
2
Author Information
1. 首都医科大学康复医学院，北京 100069
2. 中国康复研究中心北京博爱医院，北京 100068
- Publication Type:Journal Article
- Keywords:
Immunophenotype;
Ischemic stroke;
Mendelian randomization
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(2):147-154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between 731 immunophenotypes and the risk of ischemic stroke based on the summary statistics from the largest publicly available genome-wide association studies. Methods The univariate Mendelian randomization （MR） analysis and multivariate Mendelian randomization （MVMR） analysis were used to investigate the association between 731 immunophenotypes and the risk of ischemic stroke. The types of immune cells significantly associated the risk of ischemic stroke were identified after false discovery rate （FDR） correction. The reverse MR analysis was used to validate the influence of immunophenotypes on ischemic stroke， and the sensitivity analysis was performed for all results to ensure stability. Results The univariate MR analysis identified four types of immune cells that were significantly associated with the risk of ischemic stroke，i.e.，CD39+ regulatory T cells （OR=1.017，95%CI 1.008-1.025，P<0.000 1），IgD-CD38+B cells with CD27+ phenotype （OR=1.073，95%CI 1.034-1.114，P<0.001），CD14+CD16-monocytes with CD40+phenotype （OR=0.973，95%CI 0.959-0.987，P<0.001），and CD14+CD16+ monocytes with CD40 phenotype （OR=0.979，95%CI 0.969-0.990，P<0.001）. The MVMR analysis showed that IgD-CD38+cells with CD27+phenotype had a significant independent effect in increasing the risk of ischemic stroke （OR=1.053，95%CI 1.006-1.100，P=0.028）. The reverse MR analysis did not yield statistically significant results after FDR correction， and the sensitivity analysis confirmed the stability of these findings. Conclusion This study shows that immunophenotype has a significant impact on the risk of ischemic stroke， and further experimental studies are needed to explore the underlying mechanisms of these associations.
- Full text:2025071516113026656免疫表型与缺血性卒中风险的因果关联_孟德尔随机化研究.pdf
