Relationship between mitochondrial biogenesis abnormalities and Parkinson disease
10.19845/j.cnki.zfysjjbzz.2025.0025
- VernacularTitle:线粒体生物发生异常与帕金森病的相关性
- Author:
Xiaorui QIU
1
;
Guofeng YANG
1
Author Information
1. Department of Geriatrics， The Second Hospital of Hebei Medical University， Shijiazhuang 050000， China
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Mitochondria;
Mitochondrial biogenesis;
PGC-1α;
α-synuclein;
Dopaminergic neurons
- MeSH:
Parkinson Disease
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(2):126-132
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson disease is a neurodegenerative disorder with motor and cognitive impairments as the main clinical symptoms. The disease is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of Lewy bodies， which are eosinophilic inclusions composed of α-synuclein， in the remaining dopaminergic neurons. The disease predominantly affects middle-aged and elderly individuals. Oxidative stress caused by mitochondrial dysfunction can lead to the loss of dopaminergic neurons， so mitochondrial dysfunction is considered as the main cause of Parkinson disease. Mitochondrial biogenesis has an important effect on the function of mitochondria. Therefore， abnormality of the regulation system of mitochondrial biogenesis is closely related to the occurrence and development of Parkinson disease. This review focuses on the regulatory mechanism of mitochondrial biogenesis control system and aims to provide promising therapeutic targets for Parkinson disease.
