Depression and anxiety and their influence on quality of life in patients with Parkinson disease in Tibet， China
10.19845/j.cnki.zfysjjbzz.2025.0021
- VernacularTitle:西藏地区帕金森病患者焦虑抑郁状态及对生活质量的影响
- Author:
Yi WANG
1
,
2
;
Dunzhu MIMA
2
;
Lin WANG
2
,
3
Author Information
1. 西藏大学医学院，西藏自治区 拉萨 850000
2. 西藏自治区人民医院神经内科，西藏自治区 拉萨 850000
3. 中国医学科学院北京协和医院神经科，北京 100730
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Plateau;
Depression;
Anxiety;
Quality of life
- MeSH:
Parkinson Disease;
Depression;
Anxiety
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(2):104-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the state of anxiety and depression in patients with Parkinson disease due to high-altitude exposure in Tibet， China and its impact on quality of life. Methods A total of 93 patients with Parkinson disease who attended Tibet Autonomous Region People’s Hospital from February 2023 to November 2024 were enrolled， and basic information and assessment scales were collected. The Unified Parkinson’s Disease Rating Scale Part Ⅲ （UPDRS-Ⅲ） and Hoehn-Yahr （H-Y） stage were used to evaluate disease severity； Parkinson’s Disease Quality of Life Questionnaire （PDQ-39） was used to evaluate the quality of life of patients； the diagnostic criteria for depression and anxiety in Parkinson disease were used for the diagnosis of depression and anxiety in patients with Parkinson disease； Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale （HAMA） were used to assess the severity of depression and anxiety. Results Among the 93 patients with Parkinson disease， the prevalence rates of depression and anxiety were 59.1% and 44.1%， respectively. There were significant differences between the depression group and the non-depression group in the somatization， despair， cognitive impairment， block factor， and day-night changes of anxiety， but there were no significant differences in sleep disorders and body weight between the two groups. The depression group had significantly higher PDQ-39 scores than the non-depression group， and the anxiety group had significantly higher PDQ-39 scores than the non-anxiety group. Depressive state was negatively correlated with folate and was positively correlated with blood homocysteine. Anxiety state was positively correlated with H-Y stage and UPDRS Ⅲ score. Conclusion There are relatively high prevalence rates of depression and anxiety in patients with Parkinson disease in Tibetan plateau area， which significantly affects the quality of life of patients.
- Full text:2025071513354735564西藏地区帕金森病患者焦虑抑郁状态及对生活质量的影响.pdf
