Mitochondrial-regulated Tregs： Research advances in potential therapeutic targets for autoimmune diseases of the central nervous system
10.19845/j.cnki.zfysjjbzz.2025.0015
- VernacularTitle:线粒体调节的Tregs：中枢神经系统自身免疫性疾病潜在治疗靶点的研究进展
- Author:
Aoya HAN
1
;
Nanchang XIE
1
Author Information
1. Department of Neurology， The First Affiliated Hospital of Zhengzhou University， Zhengzhou 450052，China
- Publication Type:Journal Article
- Keywords:
Mitochondrion;
Regulatory T cell;
Central nervous system autoimmune disease;
FoxP3
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(1):70-76
- CountryChina
- Language:Chinese
-
Abstract:
Regulatory T cells （Tregs） can clear autoreactive lymphocytes， induce self-tolerance， and suppress inflammatory response. As the energy factories of cells， mitochondria are critical for the function， differentiation， and survival of Tregs. Studies have found Treg abnormalities and mitochondrial damage in patients with central nervous system autoimmune diseases， such as multiple sclerosis， neuromyelitis optica spectrum disorder， and autoimmune encephalitis. However， the role of mitochondrial-regulated Tregs in central nervous system autoimmune diseases remains inconclusive. Therefore， this review focuses on the effects of mitochondrial damage on Tregs in central nervous system autoimmune diseases and the possible mitochondrial therapeutic targets.
- Full text:2025071513035543343线粒体调节的Tregs_中枢神经系统自身免疫性疾病潜在治疗靶点的研究进展.pdf
