Safety and efficacy of mechanical thrombectomy combined with umbilical cord blood mononuclear cell transplantation in improving the prognosis of patients with acute ischemic stroke due to large vessel occlusion
10.19845/j.cnki.zfysjjbzz.2025.0010
- VernacularTitle:机械取栓联合脐带血单个核细胞移植改善急性颅内大血管闭塞性缺血性脑卒中患者预后的研究
- Author:
Zhongchen LI
1
,
2
;
Liyong ZHANG
1
,
2
Author Information
1. Liaocheng People&rsquo
2. s Hospital， Liaocheng 252000， China
- Publication Type:Journal Article
- Keywords:
Acute large vessel occlusion;
Cerebral infarction;
Mechanical thrombectomy;
Umbilical cord blood mononuclear cell;
Treatment efficacy
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(1):47-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the safety and efficacy of mechanical thrombectomy combined with umbilical cord blood mononuclear cell microtransplantation in the treatment of patients with acute ischemic stroke due to large vessel occlusion. Methods A prospective study was conducted among 61 patients with acute ischemic stroke due to large vessel occlusion in the anterior intracranial circulation who underwent mechanical thrombectomy in our hospital from February 2021 to February 2023， and they were randomly divided into experimental group and control group. The patients in the experimental group underwent mechanical thrombectomy combined with umbilical cord blood mononuclear cell microtransplantation， while those in the control group underwent mechanical thrombectomy alone， and there was no difference in conventional drug treatment between the two groups. The Mann-Whitney U test， chi-square test， and logistic regression analysis were used， with P<0.05 indicating statistical significance. Results There were no significant abnormalities in blood tests and imaging findings in either group at 90 days and 6 months after treatment. There was no significant difference in the degree of neurological deficit （NIHSS score） between the two groups before surgery and on days 1，3，7， and 30 after surgery （P>0.05）. The experimental group had a higher overall response rate （the proportion of patients with an mRS score of ≤2 on day 90 after surgery） than the control group [41.4% （12/29） vs 32.2% （10/31）， P>0.05]. There was no significant difference in limb motor function [Fugl-Meyer Assessment （FMA） score] between the two groups before surgery（P>0.05）， and the experimental group had a better FMA score than the control group on day 90 after surgery（P<0.05）. Conclusion Mechanical thrombectomy combined with umbilical cord blood mononuclear cell microtransplantation can effectively improve the long-term functional prognosis of patients， with a favorable safety profile.
- Full text:2025071510140542359机械取栓联合脐带血单个核细胞移植改善急性颅内大血管闭塞性缺血性脑卒中患者预后的研究.pdf
