Research progress of new aluminum-containing vaccine adjuvants
10.11665/j.issn.1000-5048.2024122301
- VernacularTitle:新型含铝疫苗佐剂的研究进展
- Author:
Hongmei REN
1
;
Yerong XIONG
;
Xiaoying XUN
;
Lei JIANG
;
Jiasheng TU
Author Information
1. 中国药科大学药学院, 药用辅料及仿创药物研发评价中心, 南京210009
- Publication Type:Journal Article
- Keywords:
vaccine;
aluminum adjuvant;
nano-aluminum adjuvant;
composite aluminum adjuvant;
immune response
- From:
Journal of China Pharmaceutical University
2025;56(2):236-243
- CountryChina
- Language:Chinese
-
Abstract:
Aluminum adjuvants are widely used in the field of vaccines due to their ability to induce efficient and long-lasting immune responses and good safety profile. With the development of immunology, the requirements for adjuvants have gradually increased, and traditional aluminum adjuvants can no longer meet all the needs of application. The development of novel aluminum adjuvants has become a hot research topic in order to achieve good immunity-enhancing effects and induce specific types and strengths of immune responses. This review briefly introduces the mechanism of action and safety of aluminum adjuvants, with focus on the research progress of novel aluminum adjuvants in recent years, mainly including nano-aluminum adjuvants and composite aluminum adjuvants (aluminum adjuvants compounded with immunity-stimulating molecules or delivery carriers), and a prospect of their future research direction, aiming to provide some reference for the further development and clinical application of aluminum adjuvants.
