Wogonin ameliorates Aβ1-42 and D-galactose-induced learning and memory impairment in mice
10.11665/j.issn.1000-5048.2024091301
- VernacularTitle:汉黄芩素对Aβ1-42和D-半乳糖诱导的小鼠学习记忆损害的改善作用
- Author:
Qilu ZHANG
1
,
2
,
3
;
Ruizhe NIE
;
Libin WEI
;
Qinglong GUO
;
Susu TANG
Author Information
1. 中国药科大学药学院药理系, 南京211198
2. 中国药科大学基础医学与临床药学学院生理学系, 南京211198
3. 山东益康药业股份有限公司, 山东省晶型药物重点实验室, 滕州277500
- Publication Type:Journal Article
- Keywords:
wogonin;
Aβ1-42;
D-galactose;
memory impairment;
apoptosis
- From:
Journal of China Pharmaceutical University
2025;56(2):207-215
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of Wogonin (WO) on learning and memory impairment, Aβ1-42 was injected intracerebroventricularly to induced a mouse learning and memory impairment model, and D-galactose was injected intraperitoneally to induced a mouse acute aging model. Mice were administered WO (75, 150, or 300 mg/kg) by oral gavage for 28 consecutive days. Cognitive function was assessed using the Morris water maze (MWM), novel object recognition (NOR), and open field tests (OFT). In the Aβ1-42 model, WO treatment (150 and 300 mg/kg) significantly improved the recognition index in the NOR test, while the 150 mg/kg group showed increased target quadrant preference in the MWM test. No changes in the total distance traveled in OFT. In the D-galactose aging model, the 150 mg/kg WO group exhibited increased platform crossings in the MWM test, and all WO doses (75, 150, and 300 mg/kg) enhanced target quadrant preference, with no alterations in spontaneous movement. Western blot analysis revealed that WO significantly attenuated hippocampal apoptosis in both models. These findings suggest that WO ameliorates learning and memory impairment associated with Alzheimer’s disease and aging.
