Value of pontine volume in diagnosis and differential diagnosis of multiple system atrophy with predominant cerebellar ataxia
10.19845/j.cnki.zfysjjbzz.2025.0005
- VernacularTitle:脑桥体积对多系统萎缩C型的诊断及鉴别价值
- Author:
Tao LI
1
;
Wei LI
2
Author Information
1. 延安大学医学院，陕西 延安 716000
2. 陕西省人民医院神经内二科，陕西 西安 710068
- Publication Type:Journal Article
- Keywords:
Multiple system atrophy;
Ataxia;
Middle cerebellar peduncle width;
Pontine volume
- MeSH:
Ataxia
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(1):23-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of specific imaging parameters in the clinical diagnosis and differential diagnosis of multiple system atrophy with predominant cerebellar ataxia （MSA-C）. Methods Imaging data including pontine volume were measured for 34 patients with MSA-C who were admitted to Department of Neurology， Shaanxi Provincial People’s Hospital， from January 2021 to October 2024， and these patients were compared with 9 patients with progressive supranuclear palsy （PSP）， 8 patients with spinocerebellar ataxia （SCA）， and 32 normal controls. Results There was a significant difference in pontine volume between the MSA-C group and the PSP group， as well as between the MSA-C group and the normal control group （P<0.008 3）， while there was no significant difference between the MSA-C group and the SCA group （P>0.008 3）. There was no significant difference in pontine volume between the PSP group and the SCA group and between the PSP group and the normal control group （P>0.008 3）， and there was a significant difference in pontine volume between the SCA group and the normal control group （P<0.008 3）. The receiver operating characteristic （ROC） curve analysis showed that pontine volume had a cut-off value of 8.66 cm3 in the diagnosis of MSA-C， with an area under the ROC curve （AUC） of 0.972， a sensitivity of 94.12%， and a specificity of 100%； pontine volume had a cut-off value of 8.66 cm3 in the differential diagnosis of MSA-C from PSP， with an AUC of 0.961， a sensitivity of 94.1%， and a specificity of 100%； pontine volume had a cut-off value of 6.79 cm3 in the differential diagnosis of MSA-C from SCA， with an AUC of 0.783， a sensitivity of 52.94%， and a specificity of 100%. Conclusion As the most objective indicator for evaluating pontine atrophy， pontine volume has a great significance in the diagnosis and differential diagnosis of MSA-C.
- Full text:2025071509270814917脑桥体积对多系统萎缩C型的诊断及鉴别价值.pdf
