Effect of chemical modification on biological properties of hyaluronic acid

VernacularTitle:化学改性对透明质酸生物学性质的影响
Author: Yue JIA ^{1
,

2
,

3} ; Hengchuan ZHANG ; Yuanyuan ZHAO ; Shaoping YIN ; Tingjie YIN
Author Information

1. 中国药科大学药学院, 南京 210009
2. 南京中医药大学药学院, 南京 210023
3. 河北省药品医疗器械检验研究院, 石家庄 050200
Publication Type:Journal Article
Keywords: hyaluronic acid; chemical modification; biological properties
From: Journal of China Pharmaceutical University 2025;56(1):119-124
CountryChina
Language:Chinese
Abstract: Hyaluronic acid (HA) possesses excellent biocompatibility, biodegradability, and non-immunogenicity, and exhibits active targeting capability to receptors such as cluster of differentiation 44 (CD44). Therefore, HA has become an important material for the design and preparation of drug delivery carriers in recent years. HA is rich in functional groups that can be chemically modified, but different modification methods and sites can affect its biological properties. This paper summarizes and discusses the effects of chemical modification on the biological properties of HA based on the formation mechanisms of such properties, as well as the derivatization and characterization methods of HA, so as to provide some reference for rational research on chemical modification of HA.