Therapeutic effect and mechanism of the topical preparation of baicalein on atopic dermatitis
10.11665/j.issn.1000-5048.2024070302
- VernacularTitle:黄芩素外用制剂对特应性皮炎的治疗作用及其机制
- Author:
Deng WANG
1
,
2
,
3
;
Zhongying FAN
;
Qinglong GUO
;
Xi LI
;
Yujie BAI
;
Libin WEI
;
Yuan HE
Author Information
1. 中国药科大学基础医学与临床药学学院, 南京211198
2. 南京芩领医药科技有限公司, 南京210032
3. 山东益康药业股份有限公司, 山东省晶型药物重点实验室, 滕州 277500
- Publication Type:Journal Article
- Keywords:
atopic dermatitis;
baicalein;
topical preparations;
inflammatory factors;
NF-κB p65
- From:
Journal of China Pharmaceutical University
2025;56(1):99-109
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the therapeutic effect of baicalein topical preparation on atopic dermatitis, we first constructed two atopic dermatitis-like mouse models induced by calcipotriol and 1-fluoro-2,4-dinitrobenzene to assess their therapeutic effect with skin tissue staining and other experiments. It was found that topical preparation of baicalein could alleviate epidermal thickening of diseased skin tissues, repair damaged skin barrier proteins, and inhibit T helper 2 cells (Th2) infiltration and mast cell infiltration and activation in lesional sites. Cyberpharmacology was utilized to analyze whether baicalein could treat atopic dermatitis by interfering with multiple pathogenesis-associated pathways. Results indicated that baicalein reduced the mRNA levels of inflammatory factors and inhibited the phosphorylation of NF-κB p65 and STAT1 proteins in keratinocyte cells. Together, the topical preparation of baicalein may be effective in alleviating atopic dermatitis-like symptoms in mice by down-regulating the phosphorylation level of NF-κB in keratinocytes, thereby decreasing the expression of inflammatory factors in keratinocytes, which provides an idea and a theoretical basis for the topical preparation of baicalein for the treatment of inflammatory skin diseases such as atopic dermatitis.
