Research progress of acetylation in the pathogenesis of MASLD
10.11665/j.issn.1000-5048.2024030103
- VernacularTitle:代谢功能障碍相关脂肪性肝病中蛋白乙酰化修饰的研究进展
- Author:
Li YAN
1
,
2
;
Fengyu JU
;
Xin SHEN
;
Ye YU
;
Wenhui WANG
Author Information
1. 中国药科大学基础医学与临床药学学院, 南京 211198
2. 中国药科大学药学院, 南京 211198
- Publication Type:Journal Article
- Keywords:
metabolic dysfunction-associated steatotic liver disease;
metabolic dysfunction–associated steatohepatitis;
acetylation;
acetylase
- From:
Journal of China Pharmaceutical University
2025;56(1):31-39
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent cause of chronic liver disease worldwide, and its intricate pathogenesis presents challenges in the development of new drugs. As a common way of post-translational modification, acetylation regulates protein stability, enzyme activity, and subcellular localization, occurring extensively in MASLD-associated processes such as lipid metabolism, inflammatory response, and oxidative stress. In this paper, we comprehensively review the mechanism of acetylation in MASLD, analyze the expression levels of acetylases in liver tissues of MASLD patients from the gene expression omnibus (GEO), discuss the changes in relevant enzyme expression and mechanisms in animal models, and further explore the feasibility of targeting acetylation for MASLD treatment, in the hope of offering a new perspective for advancing drug discovery in the field of MASLD.
