Application Value of Organoid Technology in the Research of Traditional Chinese Medicine for the Prevention and Treatment of Digestive System Diseases
10.13288/j.11-2166/r.2025.14.005
- VernacularTitle:类器官技术在中医药防治消化系统疾病研究中的应用价值
- Author:
Yongtian WEN
1
;
Xiangxue MA
2
;
Beihua ZHANG
1
;
Fengyun WANG
1
;
Xudong TANG
1
Author Information
1. Department of Gastroenterology，Xiyuan Hospital，China Academy of Chinese Medical Sciences，Beijing 100091
2. The First Affiliated Hospital of Guangzhou University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
organoid technology;
digestive system diseases;
disease models;
drug screening;
traditional Chinese medicine study
- From:
Journal of Traditional Chinese Medicine
2025;66(14):1433-1438
- CountryChina
- Language:Chinese
-
Abstract:
Organoid technology， a rapidly advancing three-dimensional （3D） cell culture platform， can closely mimic the microarchitecture and functions of human digestive organs， effectively overcoming the limitations of conventional two-dimensional cell models and animal experiments. By systematically summarizing the distinctive strengths of organoid technology in simulating digestive physiological and pathological states， constructing digestive system disease models， enabling high-throughput drug screening， and facilitating personalized treatment， this review explored the potential applications of organoids in identifying active components of traditional Chinese medicine （TCM） formulas， evaluating in vitro pharmacokinetics and toxicological parameters， and investigating multi-target synergistic mechanisms. By integrating cutting-edge engineering technologies， organoids are expected to provide a more scientific research platform for TCM， accelerate the modernization of its mechanistic studies， and enhance its scientific value and global impact.
