Causal relationship between pneumoconiosis and five mental disorders analyzed by two-sample Mendelian randomization study
10.20001/j.issn.2095-2619.20250404
- VernacularTitle:双样本孟德尔随机化分析尘肺病与5种精神障碍的因果关系
- Author:
Siyuan GAO
1
;
Ming CHEN
;
Lishi CHEN
;
Yushuo LIANG
;
Zhisheng LAI
;
Ying CHENG
;
Leilei HUANG
Author Information
1. Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, Guangdong 510300, China
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
Pneumoconiosis;
Depression;
Bipolar disorder;
Schizophrenia;
Insomnia;
Anxiety
- From:
China Occupational Medicine
2025;52(2):143-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential causal relationship between occupational pneumoconiosis (hereinafter referred to as "pneumoconiosis") and five mental disorders (depression, bipolar disorder, schizophrenia, insomnia and anxiety) using the two-sample Mendelian randomization (MR) method. Methods Single nucleotide polymorphisms (SNPs) loci associated with pneumoconiosis and five mental disorders were screened from Genome-Wide Association Studies. Inverse variance weighting (IVW), weighted median (WM) and MR-Egger regression methods were used to evaluate the significance of the causal relationship between pneumoconiosis and five mental disorders. Sensitivity analysis was used to evaluate the accuracy and reliability of the research results. Results After matching data of pneumoconiosis and the five mental disorders, 16 SNPs were ultimately included as instrumental variables in this study. The result of MR analysis revealed a positive causal relationship between pneumoconiosis and both depression [IVW: odds ratio (OR) and 95% confidence interval (CI) was 1.017 (1.000-1.035), P<0.05] and bipolar disorder [IVW: OR(95%CI)was 1.046(1.009-1.083), P<0.05; WM: OR (95%CI) was 1.055(1.007-1.105), P<0.05]. Result of sensitivity analysis indicated there was no heterogeneity and horizontal pleiotropy in the above results. There was no causal association observed between pneumoconiosis and schizophrenia, insomnia, or anxiety disorders (all P>0.05). Conclusion This study provides genetic evidence supporting a positive causal relationship between pneumoconiosis and both depression and bipolar disorder.
