Treatment of Asthma by Regulation of Intestinal Flora in Traditional Chinese Medicine Based on "Lung-Intestinal Coordination Therapy"
10.13422/j.cnki.syfjx.20250606
- VernacularTitle:基于“肺肠合治法”探讨中医调控肠道菌群治疗哮喘的研究进展
- Author:
Wei ZHANG
1
;
Jie SHI
2
;
Xishu TAN
2
;
Yule KOU
2
;
Fei WANG
1
Author Information
1. The First Clinical Medical Faculty，Shaanxi University of Chinese Medicine，Xianyang 712000，China
2. Affiliated Hospital of Shaanxi University of Chinese Medicine，Xianyang 712000，China
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
lung-intestinal coordination therapy;
traditional Chinese medicine;
intestinal flora;
lung-gut axis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(16):307-314
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma （asthma） is a heterogeneous disease characterized by airflow limitation， airway remodeling， and recurrent symptoms such as wheezing， shortness of breath， chest tightness， and cough. Its prevalence is gradually increasing， and a portion of patients are still poorly controlled， leading to a serious social and medical burden. Modern studies have proposed the concept of the "lung-gut axis"， which is based on the crosstalk between microorganisms and their metabolites in the lungs and large intestine， and have indicated that microbial dysbiosis in these organs may affect the onset and progression of asthma. Traditional Chinese medicine （TCM） has found the phenomenon of lung-intestinal comorbidity and put forward the importance of "lung-intestinal coordination therapy" in the treatment of lung-related diseases. It has been found that intestinal flora and their metabolites can modulate immune responses through the lung-gut axis， demonstrating great potential for predicting asthma susceptibility， anticipating phenotypes， assessing asthma severity， and guiding treatment. TCM comopunds that embody lung-intestinal coordination therapy， including herbal formulas， single herbs， acupuncture， moxibustion， acupoint application， and spinal pinching therapy， has been shown to regulate intestinal flora， improve metabolism， regulate immunity， alleviate lung inflammation， reduce mucus secretion， inhibit airway remodeling， effectively alleviate symptoms， and delay lung function decline. Based on "lung-intestinal coordination therapy"， this paper used intestinal flora as the entry point to summarize the underlying mechanisms of TCM in asthma treatment and highlighted the pivotal role of intestinal flora in asthma， providing a new idea for its clinical treatment through the intestinal flora .
