Research Progress on Immunomodulatory Activity and Mechanism of Polygonatum sibiricum
10.13422/j.cnki.syfjx.20250842
- VernacularTitle:黄精免疫调节活性及机制的研究进展
- Author:
Jinyu LI
1
;
Ningning QIU
1
;
Chang YI
1
;
Mengqin ZHU
1
;
Yanfeng YUAN
1
;
Guang CHEN
1
;
Xili ZHANG
1
;
Wenlong LIU
1
Author Information
1. Pharmacy school， Hunan University of Chinese Medicine， Changsha 410208， China
- Publication Type:Journal Article
- Keywords:
Polygonatum sibiricum;
immune regulation;
active ingredients;
tonifying traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(16):298-306
- CountryChina
- Language:Chinese
-
Abstract:
Polygonatum sibiricum， as a traditional Chinese medicine with both medicinal and edible properties， has attracted considerable attention due to its functions of nourishing Yin and moistening the lungs， tonifying the spleen and benefiting Qi， and nourishing the kidneys and filling essence. Recent studies have demonstrated that Polygonatum sibiricum plays a significant role in regulating the immune system， effectively enhancing and improving the morphology and function of immune organs， stimulating the proliferation and activation of immune cells， and regulating the secretion and release of immune factors， thereby enhancing the immune function of the body and improving various immune-related diseases. Although a large number of studies have explored the pharmacological effects and mechanisms of P. sibiricum， there has been no systematic review and summary of its immune regulatory activity and mechanisms. Therefore， this article comprehensively reviews the research achievements of P. sibiricum polysaccharides and saponins in the field of immune regulation in recent years， and further sorts out the immune regulatory mechanisms of P. sibiricum in multiple aspects： including increasing the organ index of the spleen and thymus， increasing the number and activity of tumor-suppressive bone marrow hematopoietic stem cells， improving intestinal flora imbalance， regulating the quantity and proportion of T lymphocyte subsets， increasing the level of immunoglobulin， promoting the proliferation of macrophages， enhancing the activity of natural killer cells， increasing the number of white blood cells， and promoting the maturation of dendritic cells， providing a solid theoretical basis and scientific evidence for the research and application of P. sibiricum， and promoting its development and application in traditional Chinese medicine immune enhancers and various functional products.
