Treatment of Precancerous Lesions of Chronic Atrophic Gastritis with Traditional Chinese Medicine via Regulating PI3K/Akt Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20251893
- VernacularTitle:中医药调控PI3K/Akt信号通路治疗慢性萎缩性胃炎癌前病变的研究进展
- Author:
Xin CHEN
1
;
Rongshi SHAO
1
;
Xiaoming ZHOU
1
;
Huili SUN
1
Author Information
1. Nantong Hospital Affiliated to Nanjing University of Chinese Medicine，Nantong 226001，China
- Publication Type:Journal Article
- Keywords:
chronic atrophic gastritis;
gastric precancerous lesion;
phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）;
signaling pathway;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(16):288-297
- CountryChina
- Language:Chinese
-
Abstract:
Chronic atrophic gastritis （CAG），as a key stage of precancerous lesions of gastric cancer，has an increasing incidence year by year，and it can gradually develop into gastric invasive cancer and mucosal cancer. At present，the main treatment focuses on the eradication of Helicobacter pylori （Hp），drug therapy， and pathological follow-up by gastroscopy，which can alleviate some symptoms，but it is difficult to curb the pathological progress，and the recurrence rate is high. Phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway is involved in the regulation of cell growth，differentiation，proliferation，apoptosis，autophagy， and other responses，and abnormal activation of this pathway can promote the progression of precancerous lesions of CAG. Traditional Chinese medicine is effective in the treatment of precancerous lesions of CAG through multi-component and multi-target comprehensive regulation. By regulating the PI3K/Akt pathway，the active ingredients and compounds of traditional Chinese medicine play therapeutic roles，such as inhibiting inflammation，glycolysis，angiogenesis， and epithelium-mesenchymal transformation，promoting autophagy，and regulating the balance of cell proliferation and apoptosis. This paper systematically reviewed the mechanism of traditional Chinese medicine intervention in the PI3K/Akt pathway in the treatment of precancerous lesions of CAG，so as to provide references for further understanding of the pathogenesis of precancerous lesions of CAG and search for potential therapeutic targets，and it provided new ideas for further research and drug development of precancerous lesions of CAG.
