Analysis of Animal Model of Anxiety Disorder Based on Clinical Characteristics of Syndromes in Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20250603
- VernacularTitle:基于中西医临床病证特点的焦虑症动物模型分析
- Author:
Baoling HUANG
1
;
Yilong HU
1
;
Jingying YANG
1
;
Mingsan MIAO
2
Author Information
1. School of Pharmacy， Henan University of Chinese Medicine， Zhengzhou 450046， China
2. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao， Henan University of Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Journal Article
- Keywords:
anxiety disorder;
characteristic of disease and syndrome;
animal model;
behavior science;
integration of traditional Chinese and western medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(16):235-242
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThis study aims to analyze animal models of anxiety disorder based on the clinical characteristics of anxiety disorder in traditional Chinese and Western medicine， systematically assess the clinical compatibility， and provide suggestions for the construction of animal models with a high degree of clinical compatibility between traditional Chinese and Western medicine. MethodsRelevant literature on animal models of anxiety disorder was retrieved from global databases. Scoring scales were developed according to the etiology， pathogenesis， and diagnostic criteria of anxiety disorder in both traditional Chinese and Western medicine. The animal models of anxiety disorder in the literature were analyzed， and their clinical compatibility was systematically assessed to identify reference-worthy models. ResultsThe average clinical compatibility of existing animal models of anxiety disorder was 42.13% for traditional Chinese medicine and 50.94% for Western medicine. Among these， the chronic unpredictable mild stress （CUMS） model had the highest compatibility with both traditional Chinese and Western medicine. However， current models rarely reflect the clinical syndromes of traditional Chinese medicine in depth， and show limitations in syndrome differentiation. ConclusionThe existing animal models of anxiety disorder are mostly established using single-factor approaches， which fail to comprehensively simulate the onset process and physiopathological characteristics of anxiety disorder. These models also neglect the syndrome-based indicators emphasized in traditional Chinese medicine. In the future， the model development should incorporate the clinical characteristics of syndromes in both traditional Chinese and Western medicine， establish standardized evaluation criteria for anxiety disorder models， and utilize multifactorial approaches to enhance the representativeness of animal models in traditional Chinese medicine.
