Mechanisms and repair strategies of ischemia-reperfusion injury in steatotic donor livers
10.12464/j.issn.1674-7445.2025093
- VernacularTitle:脂肪变性供肝缺血-再灌注损伤的发生机制及修复策略
- Author:
Huangyan ZHANG
1
;
Jie JIANG
2
;
Zongqiang HU
2
Author Information
1. School of Medicine, Kunming University, Kunming 650000, China.
2. .
- Publication Type:ReviewArticle
- Keywords:
Steatotic donor liver;
Ischemia-reperfusion injury;
Marginal donor liver;
Reactive oxygen species;
Mitochondrial dysfunction;
Inflammatory response;
Ferroptosis;
Non-alcoholic steatotic liver
- From:
Organ Transplantation
2025;16(4):620-625
- CountryChina
- Language:Chinese
-
Abstract:
The shortage of donor livers has become the main obstacle restricting the clinical development of liver transplantation. The rational use of marginal donor livers is an effective way to alleviate the shortage of donor livers. With the development of society and the changes in people's diet and lifestyle, the incidence of obesity and steatotic liver disease are continuously increasing. Steatotic livers provide an opportunity to alleviate the shortage of donor livers by expanding the donor pool. Many studies have shown that compared with normal donor livers, steatotic donor livers are more sensitive to ischemia-reperfusion injury. This review will summarize the current mechanisms and repair strategies of ischemia-reperfusion injury in steatotic livers, providing references for the rational use of steatotic donor livers and ideas for expanding the donor pool for liver transplantation.
