Effects of donor gender on short-term survival of lung transplant recipients: a single-center retrospective cohort study
10.12464/j.issn.1674-7445.2025062
- VernacularTitle:供者性别对肺移植受者术后短期生存的影响：一项单中心回顾性队列研究
- Author:
Xiaoshan LI
1
,
2
;
Shiqiang XUE
3
;
Min XIONG
3
;
Rong GAO
2
;
Ting QIAN
3
;
Lin MAN
3
;
Bo WU
3
;
Jingyu CHEN
1
,
2
Author Information
1. Department of Lung Transplantation Center, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China
2. .
3. Department of Lung Transplantation Center, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China.
- Publication Type:OriginalArticle
- Keywords:
Lung transplantation;
Donor;
Gender matching;
Donor lung allocation;
Short-term survival;
Lung allocation score;
Propensity score regression;
Propensity score matching
- From:
Organ Transplantation
2025;16(4):591-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of donor gender on short-term survival rate of lung transplant recipients. Methods A retrospective analysis was conducted on the data of 1 066 lung transplant recipients. The log-rank test was used to evaluate the differences in short-term fatality among different donor gender groups and donor-recipient gender combination groups. Multivariate Cox regression, propensity score (PS) regression, and propensity score matching (PSM) were employed to control for confounding factors and further assess the differences in fatality. Subgroup analyses were also performed based on donor gender. Results Multivariate Cox regression analysis showed no statistically significant differences in fatality at 30 days, 1 year, 2 years and 3 years postoperatively between male and female donor groups (all P>0.05). After PS regression and PSM, univariate Cox regression analysis indicated that recipients from female donors had a higher fatality at 2 years postoperatively compared to those from male donors, with hazard ratios (95% confidence intervals) of 1.29 (1.01-1.65) and 1.36 (1.03-1.80) respectively. Multivariate Cox regression analysis also revealed no statistically significant differences in fatality at various follow-up time points among different donor-recipient gender combination groups (all P>0.05). Subgroup analyses based on donor sex showed no statistically significant differences in fatality among recipients of different gender within either male or female donor groups (all P>0.05). Conclusions Female donors may reduce the short-term postoperative survival rate of lung transplant recipients, but this negative impact is not sustainable in the long term. At present, there is no evidence to support the inclusion of sex as a factor in lung allocation rules.
