Current status and prospects of new desensitization measures in ABO-incompatible liver transplantation
10.12464/j.issn.1674-7445.2025127
- VernacularTitle:新型脱敏措施在ABO血型不合肝移植中的应用现状及展望
- Author:
Teng FANG
1
,
2
;
Wu ZHANG
2
Author Information
1. Medical Department of Hangzhou Normal University, Hangzhou 310000, China
2. .
- Publication Type:TransplantationForefront
- Keywords:
New desensitization measure;
ABO-incompatibility;
Liver transplantation;
Antibody-mediated rejection;
Double filtration plasmapheresis;
Antibody-dependent cell-mediated cytotoxicity;
Bone marrow-mesenchymal stem cell;
Adipose derived-mesenchymal stem cell
- From:
Organ Transplantation
2025;16(4):509-515
- CountryChina
- Language:Chinese
-
Abstract:
In the field of liver transplantation, due to the shortage of donor livers, ABO-incompatible donor livers, as a type of marginal donor livers, have expanded the source of donors for end-stage renal disease patients who are on the brink of death while waiting for liver transplantation. With the continuous progress of various desensitization techniques in the perioperative period, desensitization treatment for ABO-incompatible liver transplantation has achieved certain effects, but the incidence of postoperative complications remains high. In recent years, with the emergence of new desensitization measures, the therapeutic effect of ABO-incompatible liver transplantation has been further improved, but the mechanisms of action and the synergistic effects of drugs still need to be further explored. Given this, this article provides a review of the mechanisms of action, current clinical applications and future development directions of various new desensitization measures. It aims to explore the feasibility of different desensitization measures in ABO-incompatible liver transplantation, provide supporting evidence for clinical application, and thereby improve the prognosis of liver transplant recipients.
