Application prospects of organoid-on-chips technology in xenotransplantation
10.12464/j.issn.1674-7445.2025082
- VernacularTitle:类器官芯片在异种器官移植中的应用前景
- Author:
Xilong LIN
1
;
Yu WANG
2
;
Jiang PENG
2
;
Hongjiang WEI
2
;
Shengkun SUN
1
Author Information
1. Department of Urology, Medical Department of the Third Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
2. .
- Publication Type:TransplantationForefront
- Keywords:
Organoid-on-a-chip;
Xenotransplantation;
Organ transplantation;
Genetically modified pig;
Matching;
Immunosuppression;
Rejection;
Virus
- From:
Organ Transplantation
2025;16(4):502-508
- CountryChina
- Language:Chinese
-
Abstract:
Xenotransplantation is an important approach to addressing the shortage of donor organs. However, it still faces numerous challenges, such as acute rejection and zoonotic diseases. Organoid-on-a-chip technology refers to a microcell culture device that simulates the physiological functions of human organs in vitro. In recent years, it has achieved a series of important results in the field of allotransplantation and has great application prospects in the field of xenotransplantation, bringing new opportunities for xenotransplantation research. Therefore, this article discusses the current research status and progress of organoid-on-a-chip technology, combined with the various problems faced by xenotransplantation, to explore the application of organoid-on-a-chip technology in solving the selection of immunosuppressive regimens, matching and viral reactivation in xenotransplantation. This aims to open up new avenues for solving the current problems in the field of xenotransplantation and promote its further development.
