Macrophages in xenotransplantation
10.12464/j.issn.1674-7445.2025138
- VernacularTitle:巨噬细胞与异种移植
- Author:
Xuyuan ZHU
1
;
Yu ZHANG
1
;
Yuxiang CHEN
1
;
Tao LI
1
;
Xiaojie MA
1
;
Hongtao JIANG
1
Author Information
1. Department of Kidney Transplantation, the Second Affiliated Hospital of Hainan Medical University, Haikou 570100, China.
- Publication Type:Editorial
- Keywords:
Macrophage;
Xenotransplantation;
Rejection;
Inflammation;
Innate immunity;
Regulatory macrophage;
Coagulation dysfunction;
Signal regulatory protein
- From:
Organ Transplantation
2025;16(4):495-501
- CountryChina
- Language:Chinese
-
Abstract:
Xenotransplantation is one of the effective ways to overcome the shortage of donor organs. However, the molecular incompatibility between xenotransplantation donors and recipients can cause rejection, which greatly limits the clinical application of xenotransplantation. In recent years, researchers have deeply explored the mechanism of xenotransplantation rejection through xenotransplantation models of pig-to-monkey and pig-to-brain death recipients, and found that the innate immune system plays an important role in rejection. Macrophages, as phagocytes in the innate immune system, not only damage xenografts through phagocytosis but also interact with other immune cells to influence the immune microenvironment of xenotransplantation. However, due to the heterogeneity of macrophages, their phenotypes and functions in xenotransplantation rejection remain unclear. Therefore, it is necessary to further explore the role of macrophages in xenotransplantation rejection. This article reviews the latest research progress of macrophages in xenotransplantation rejection, aiming to explore the mechanisms of macrophages in xenotransplantation rejection and provide references for future research.
