Research progress on exposure to per- and polyfluoroalkyl substances and adverse pregnancy outcomes
- VernacularTitle:全氟和多氟烷基物质暴露与不良妊娠结局的研究进展
- Author:
Li LU
1
;
Lishi DONG
1
;
Rongxia HE
1
Author Information
- Publication Type:Review
- Keywords: environmental pollutant; per- and polyfluoroalkyl substance; pregnancy; miscarriage; premature delivery
- From: Journal of Environmental and Occupational Medicine 2025;42(6):762-769
- CountryChina
- Language:Chinese
- Abstract: Per- and polyfluoroalkyl substances (PFAS) are a class of persistent environmental pollutants that are detected globally not only in the natural environment such as air, water, and soil, but also in animal and humans, posing a potential threat to human health. Epidemiological studies showed that PFAS exposure is closely associated with adverse pregnancy outcomes such as miscarriage, preterm birth, low birth weight and length. Studies showed that women of childbearing age have a higher risk of miscarriage and preterm birth after PFAS exposure before and during pregnancy, but the results of many studies at home and abroad are inconsistent, and it is certain that PFAS exposure is negatively correlated with birth weight and length. The mechanism of action of PFAS exposure inducing adverse pregnancy outcomes may include multiple pathways, involving oxidative stress, changes in endocrine hormone levels, abnormal glucose and lipid metabolism, and gene expression. However, the specific mechanism is still unclear. This article reviewed recent epidemiological studies on the relationships between PFAS exposure and adverse pregnancy outcomes, focusing on the effects of PFAS exposure on pregnancy outcomes, and summarized the potential mechanisms of action. This article aimed to clarify the reproductive toxicity of such chemicals, arouse the concern of women of childbearing age and pregnant women, and provide scientific basis for relevant prevention and intervention measures.
