Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanisms

Lu YU; Chihang ZHANG; Jianshu GUO; Dongxia FAN; Jinzhuo ZHAO

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Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanisms

VernacularTitle:大气颗粒物对阿尔茨海默病的影响及其潜在作用机制研究进展
Author: Lu YU ¹ ; Chihang ZHANG ¹ ; Jianshu GUO ¹ ; Dongxia FAN ¹ ; Jinzhuo ZHAO ^{2
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Author Information

1. Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200030, China.
2. Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200030, China
3. International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200030, China.
Publication Type:Review
Keywords: ambient particulate matter; Alzheimer's disease; mechanism of injury; epidemiology; toxicology
From: Journal of Environmental and Occupational Medicine 2025;42(6):748-755
CountryChina
Language:Chinese
Abstract: With the accelerating aging of world population, the prevalence and disease burden of dementia such as Alzheimer's disease is increasing annually. As one of the major risk factors for dementia, air pollution is still an urgent global concern. Studies on the association between ambient particulate matter (PM), one of the major air pollutants, and dementia, such as Alzheimer's disease, are gaining attention. This paper reviewed the current evidence of relevant epidemiological and toxicological studies to illustrate the possible mechanisms underlying the effects of PM exposure on Alzheimer's disease through inflammatory responses, oxidative stress, endocrine disruption, excitatory neurotoxicity, glial cell activation, and intestinal flora disruption, which may provide clues for mitigating the health risks of air pollution and preventing Alzheimer's disease.