Research progress on the role of parathyroid hormone and parathyroid hormone-related peptide in regulating tooth eruption
10.12016/j.issn.2096-1456.202440317
- Author:
LUO Qian
1
;
HU Yushang
1
;
YANG Kun
1
;
GE Song
1
;
ZHONG Wenyi
1
Author Information
1. Affiliated Stomatological Hospital of Zunyi Medical University
- Publication Type:Review
- Keywords:
parathyroid hormone;
parathyroid hormone related peptide;
tooth eruption;
osteoclasis;
dental follicle;
alveolar bone;
tooth root;
periodontal ligament
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(7):604-611
- CountryChina
- Language:Chinese
-
Abstract:
The emergence of teeth is a complex physiological process characterized by the formation of the tooth crown, its movement towards the occlusal plane, and subsequent penetration through the alveolar bone and oral mucosa to achieve functional positioning for contact with opposing teeth. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) are critical regulators of calcium and phosphorus metabolism in the body, playing significant roles in tooth emergence. Their regulatory functions exhibit intricate temporal and spatial dynamics, with underlying mechanisms that remain incompletely understood. In recent years, an increasing number of researchers both domestically and internationally have investigated the role and mechanisms of PTH/PTHrP in tooth emergence, primarily focusing on aspects such as dental sac formation, basal alveolar bone development, coronal alveolar bone resorption, root formation, and periodontal ligament development. Literature reviews indicate that PTH and PTHrP regulate bone metabolism, coordinate various signaling pathways including OPG/RANK/RANKL, cAMP/PKA, and Wnt/β-catenin, and are allosterically modulated by Ca2+ and ATP. These processes contribute to the development of dental sacs, which transmit signals to recruit osteoclasts and promote the resorption of crown alveolar bone, thereby forming an eruption pathway. Additionally, PTH/PTHrP plays a role in the formation of basal alveolar bone, root development, and the periodontal ligament, generating the force necessary for tooth eruption. Through precise spatiotemporal regulation and coordinated efforts, alveolar bone remodeling is achieved, facilitating the intricate process of tooth eruption. Through stringent temporal regulation and multi-faceted cooperation, remodeling of the alveolar bone occurs to complete this intricate developmental process of tooth emergence. Future research should further elucidate the mechanisms underlying PTH/PTHrP actions while also considering optimal dosage regimens regarding timing and frequency for therapeutic applications.
- Full text:2025071016492238191甲状旁腺激素与甲状旁腺激素相关肽在调节牙萌出中作用的研究进展.pdf
