Regulatory role and therapeutic effects of VEGF in intracerebral hemorrhage
10.19845/j.cnki.zfysjjbzz.2024.0219
- VernacularTitle:VEGF在脑出血中的调控机制及治疗作用
- Author:
Jingyi LI
1
;
Dongyan WANG
2
Author Information
1. 黑龙江中医药大学，黑龙江 哈尔滨 150040
2. 黑龙江中医药大学附属第二医院，黑龙江 哈尔滨 150001
- Publication Type:Journal Article
- Keywords:
Intracerebral hemorrhage;
Vascular endothelial growth factor;
Angiogenesis;
Neuroprotection;
Treatment
- MeSH:
Neuroprotection
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(12):1142-1147
- CountryChina
- Language:Chinese
-
Abstract:
In intracranial hemorrhage， the rupture of intracranial blood vessels results in elevated intracranial pressure and reduced cerebral blood flow and perfusion pressure， which directly impact blood oxygen supply to cause a series of brain injuries that are hard to recover. Angiogenesis has been demonstrated favorable for the prognosis of cerebral hemorrhage. Vascular endothelial growth factor （VEGF） is regarded as a main regulator of angiogenesis and vasculogenesis， which can regulate the pathological mechanism of cerebral hemorrhage through multiple pathways. It can not only facilitate and mediate the formation of new blood vessels to enhance oxygen and nutrient supply in bleeding areas， but also protect neural cells through alleviating inflammation， inhibiting cell apoptosis， up-regulating trophic factors， and down-regulating toxic proteins. This review focuses on the regulatory role of VEGF in the pathological process of cerebral hemorrhage as well as its effects in the treatment of cerebral hemorrhage.
- Full text:2025071013535567767VEGF在脑出血中的调控机制及治疗作用.pdf
