Research advances in copper homeostasis disorder in the pathogenesis of amyotrophic lateral sclerosis
DOI: 10.19845/j.cnki.zfysjjbzz.2024.0075
- VernacularTitle:铜稳态失调在肌萎缩侧索硬化发病机制中的研究进展
- Author:
Ying ZHANG
1
;
Yao SHAI
1
;
Hongquan JIANG
1
Author Information
1. Department of Neurology， The First Affiliated Hospital of Harbin Medical University， Harbin 150001， China
- Publication Type:Journal Article
- Keywords:
Amyotrophic lateral sclerosis;
Copper homeostasis;
ATPase copper transporting α
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(4):381-384
- CountryChina
- Language:Chinese
-
Abstract:
Copper plays an important role in maintaining the normal metabolic function of cells and participates in a variety of physiological processes in cells， including cell respiration， neuropeptide processing， and iron transport， and therefore， it is of great significance to maintain copper homeostasis. In the central nervous system， copper homeostasis is involved in the regulation of synaptic function and the formation of myelin sheath， and copper homeostasis disorder is closely associated with the development of various neurodegenerative diseases. Recent studies have shown that copper homeostasis disorder caused by the mutation of ATPase copper transporting α may lead to the development and progression of amyotrophic lateral sclerosis （ALS）. This article reviews the research advances in copper homeostasis disorder in the pathogenesis of ALS and points out that maintaining copper homeostasis may provide a new target for the treatment of ALS.
- Full text:2025071009305998132铜稳态失调在肌萎缩侧索硬化发病机制中的研究进展.pdf
