A case report of anti-NMDAR and anti-AMPAR autoimmune encephalitis with opsoclonus-myoclonus syndrome
10.19845/j.cnki.zfysjjbzz.2024.0072
- VernacularTitle:AMPA与NMDA抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征1例报告
- Author:
Jiajia JIANG
1
;
Hui BU
1
Author Information
1. Department of Neurology， The Second Hospital of Hebei Medical University， Shijiazhuang 050004， China
- Publication Type:Journal Article
- Keywords:
Autoimmune encephalitis;
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid;
N-methyl-D-aspartate;
Limbic encephalitis;
Overlap syndrome;
Opsoclonus-myoclonus syndrome
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(4):369-371
- CountryChina
- Language:Chinese
-
Abstract:
Opsoclonus-myoclonus syndrome （OMS） is a rare neurological syndrome associated with tumors， which is more common in children than in adults. It is characterized by involuntary， arrhythmic， chaotic， multidirectional saccades， usually accompanied by limb and trunk myoclonic seizures and ataxia. Case reports are even rare on OMS complicated by autoimmune encephalitis with overlapping antibodies against the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor （AMPAR） and N-methyl-D-aspartate receptor （NMDAR）， and its clinical manifestations and treatment are poorly understood. We report a case of autoimmune encephalitis with OMS positive for both NMDAR and AMPAR antibodies， and also review relevant literature to help improve the understanding of the condition.
- Full text:2025071009112631453AMPA与NMDA抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征1例报告.pdf
