Relationship between cerebral small vessel disease burden scores and cognitive function in patients with cerebral small vessel disease with asymptomatic lacunes
10.19845/j.cnki.zfysjjbzz.2024.0064
- VernacularTitle:不同脑小血管病负荷评分与伴无症状腔隙的脑小血管病患者认知功能的关系
- Author:
Xiaoguang DU
1
,
2
;
Li ZHOU
1
,
2
Author Information
1. Department of Neurology， Weifang People&prime
2. s Hospital， Weifang 261000， China
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel disease;
Cognition;
Lacune
- MeSH:
Cognition
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(4):325-328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between cerebral small vessel disease （CSVD） burden scores and cognitive function in patients with CSVD with asymptomatic lacunes. Methods A total of 128 patients with CSVD with asymptomatic lacunes who visited the Department of Neurology of Weifang People′s Hospital from July 2021 to October 2023 were included. All the patients were scored using the Montreal Cognitive Assessment （MoCA） for cognitive function and using the total CSVD score and the modified CSVD score for CSVD burden. They were divided into cognitive impairment group （MoCA score<26） and non-cognitive impairment group （MoCA score≥26）. The demographic information， vascular disease risk factors， and the CSVD scores of the two groups were compared. A linear regression analysis was performed to assess the relationship between the MoCA score and the two CSVD scores. A trend analysis was conducted to analyze the trend of incidence of cognitive impairment in patients with CSVD with asymptomatic lacunes. Results Among the 128 patients with CSVD with asymptomatic lacunes， 68 （53.1%） were in the cognitive impairment group and 60 （46.9%） were in the non-cognitive impairment group. There were no significant differences in the demographic information and vascular disease risk factors between the two groups （P>0.05）. The total CSVD score and the modified CSVD score differed significantly between the two groups （P<0.05）. The Spearman correlation analysis showed that the total and modified CSVD scores were significantly negatively correlated with the MoCA score （P<0.001）. The chi-square test for linear trend revealed that the cognitive impairment risk increased significantly with the modified CSVD score in patients with CSVD with asymptomatic lacunes （Ptrend<0.05）， but with no significance for the total CSVD score （Ptrend=0.069）. Conclusion Both the total and modified CSVD scores are useful tools to detect cognitive impairment in patients with CSVD with asymptomatic lacunes， and the modified CSVD score may be superior in identifying patients at high risk of cognitive impairment.
- Full text:2025071008255745033不同脑小血管病负荷评分与伴无症状腔隙的脑小血管病患者认知功能的关系.pdf
