Clinical features of spontaneous hypertensive intracerebral hemorrhage with different loads of cerebral small vessel disease and their association with prognosis
10.19845/j.cnki.zfysjjbzz.2024.0051
- VernacularTitle:不同脑小血管病负荷合并自发性高血压脑出血临床特征及预后相关性研究
- Author:
Zhanjun ZHENG
1
,
2
;
Xingquan ZHAO
1
Author Information
1. 首都医科大学附属北京天坛医院神经病学中心血管神经病学科，北京 100070
2. 河北燕达医院神经内科，河北 廊坊 065201
- Publication Type:Journal Article
- Keywords:
Hypertensive intracerebral hemorrhage;
Load of cerebral small vessel disease;
Clinical features;
Prognosis
- MeSH:
Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(3):259-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of spontaneous hypertensive intracerebral hemorrhage with different loads of cerebral small vessel disease （CSVD） and their association with prognosis.Methods A retrospective analysis was performed for the clinical data of the patients with hypertensive intracerebral hemorrhage who were hospitalized within 3 days after onset in Hebei Yanda Hospital from September 2017 to August 2021. Hematoma volume was calculated based on head CT scan results on admission； the severity of white matter hyperintensity， lacunae， enlarged perivascular spaces， and cerebral microbleeds was evaluated based on head MRI results after admission， and total CSVD score was calculated. The clinical features of spontaneous hypertensive intracerebral hemorrhage with different loads of CSVD and their association with prognosis were analyzed.Results A total of 113 patients with cerebral hemorrhage were included， among whom there were 69 male patients and 44 female patients， with a mean age of（61.89±12.47）years. The univariate linear regression analysis showed that sex and systolic blood pressure were associated with bleeding volume， while total CVSD score was not associated with bleeding volume. The univariate linear regression analysis showed that hypertension， history of intracranial hemorrhage， and total CVSD score were associated with NIHSS score on admission， and the multivariate logistic regression analysis showed that hypertension， history of intracranial hemorrhage， and total CVSD score were independent risk factors for high NIHSS score on admission. The univariate linear regression analysis showed that diabetes， smoking history， and total CVSD score were associated with MRS score on day 90 after discharge， and the multivariate logistic regression analysis showed that diabetes， smoking history， and total CVSD score were independent risk factors for poor prognosis.Conclusion The increase in total CSVD score may lead to the increases in the incidence rate of poor functional prognosis and NIHSS score on admission.
- Full text:2025070915264510767不同脑小血管病负荷合并自发性高血压脑出血临床特征及预后相关性研究.pdf
