The effect of sulodexide on the incidence of cardiovascular outcomes in patients with vascular disorders.

Eugenio B REYES; Paula Victoria Catherine Y CHENG-BROMEO; Nigel Jeronimo C SANTOS

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The effect of sulodexide on the incidence of cardiovascular outcomes in patients with vascular disorders.

Author: Eugenio B. REYES ¹ ; Paula Victoria Catherine Y. CHENG-BROMEO ^{1
,

2} ; Nigel Jeronimo C. SANTOS ¹
Author Information

1. Division of Cardiovascular Medicine, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Metro Manila, NCR, Philippines
2. Section of Electrophysiology and Cardiac Pacing, Division of Cardiovascular Medicine, Department of Medicine, Philippine General Hospital, University of the Philippines Manil
Publication Type:Review Articles (Literature/ Systematic /Meta-analysis)
Keywords: Microvascular Disease; Macrovascular Disease; Cardiovascular Outcomes
MeSH: Human; Sulodexide; Glucuronyl Glucosamine Glycan Sulfate
From: Philippine Journal of Cardiology 2025;53(1):87-97
CountryPhilippines
Abstract: BACKGROUND AND OBJECTIVES
Among patients with macrovascular and microvascular disease, we investigated the association between sulodexide and cardiovascular (CV) outcomes and adverse events.
METHODS
We conducted a meta-analysis of randomized control trials (RCTs) reporting CV outcomes and adverse events in patients with vascular disease receiving sulodexide for any indication versus control. The following outcomes were investigated: any CV event, myocardial infarction, CV death, bleeding events and gastrointestinal symptoms.
RESULTS
Twelve studies with a total of 8,436 patients were included. Sulodexide resulted in a significant reduction in CV events (OR 0.51 [95% confidence interval 0.41-0.73]; pCONCLUSION
Sulodexide has a beneficial effect among patients with macrovascular disease in terms of reducing the risk for MI, overall CV mortality and CV events. Larger RCTs are needed to corroborate these findings.