Hemolysis rates of three red blood cell components at the end of storage: a 5-year retrospective study
10.13303/j.cjbt.issn.1004-549x.2025.06.013
- VernacularTitle:三种红细胞成分血储存期末溶血率的5年回顾性研究
- Author:
Zhenping LU
1
;
Fufa LIU
1
;
Meiyan KANG
1
;
Xianbin WU
1
;
Yanting WANG
1
;
Xing LONG
1
;
Xinlu QIU
1
;
Jin LI
1
Author Information
1. Ganzhou Central Blood Station, Ganzhou 341000, China
- Publication Type:Journal Article
- Keywords:
red blood cell components;
hemolysis rate at the end of storage;
quality standard
- From:
Chinese Journal of Blood Transfusion
2025;38(6):828-832
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the suitability of the existing hemolysis rate standards for locally processed red blood cell components by retrospectively analyzing 5-year hemolysis rate data at the end of storage. Methods: A total of 720 blood samples of three types of red blood cell components from our blood station from January 2019 to December 2023 were collected. Parameters included hemoglobin concentration (Hb), hematocrit (Hct), and free hemoglobin concentration (fHb). Hemolysis rate were taken as the control standard of 0.8% in accordance with the national standard. The hemolysis rates were compared against the national standard threshold of 0.8% (GB18469-2012), and annual trends of the detection parameters were observed. Results: The hemolysis rates (x-+s,%) of leukocyte-depleted whole blood at the end of storage were (0.038±0.023 8) in 2019, (0.049±0.039 5) in 2020, (0.043±0.040 7) in 2021, (0.049±0.030 7) in 2022, and (0.058±0.054 8) in 2023, respectively; The hemolysis rates (x-+s" />,%) of leukocyte-depleted suspended red blood cells at the end of storage were (0.093±0.050 2) in 2019, (0.086±0.049 5) in 2020, (0.123±0.072 3) in 2021, (0.122±0.052 1) in 2022, and (0.106±0.058 6) in 2023, respectively; The hemolysis rates (x-+s,%) of washed red blood cells at the end of storage were (0.127±0.038 2) in 2019, (0.150±0.066 5) in 2020, (0.121±0.052 2) in 2021, (0.124±0.038 9) in 2022, and (0.128±0.044 3) in 2023, respectively. Conclusion: Hemolysis rates at the end of blood storage of three red blood cell components were significantly lower than the limits specified in Quality Requirements for Whole Blood and Components (GB18469-2012), as well as standards from the EU, AABB and the United States. The results demonstrate excellent product quality control. A regional internal control standard of <0.2% is proposed for hemolysis rates at the end of storage.
