Dynamic changes of iron metabolism and the effectiveness of health education among apheresis donors in Guangzhou under the GLMM framework
10.13303/j.cjbt.issn.1004-549x.2025.06.011
- VernacularTitle:GLMM框架下广州成分献血者铁代谢动态变化及健康宣教效果研究
- Author:
Xiaowen CHEN
1
;
Fanhai LI
1
;
Bi ZHONG
1
;
Guanghuan LIU
1
;
Jinyan CHEN
1
;
Hao WANG
1
;
Shijie LI
1
Author Information
1. Guangzhou Blood Center, Institute of Blood Transfusion and Hematology, Guangzhou Medical University, The Key Medical Laboratory of Guangzhou, Guangzhou 510095, China
- Publication Type:Journal Article
- Keywords:
apheresis platelets donation;
iron metabolism;
health education;
generalized linear mixed model;
non-anaemic iron deficiency
- From:
Chinese Journal of Blood Transfusion
2025;38(6):817-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the current status of iron metabolism among apheresis donors in Guangzhou and analyze the improvement effects of health education on iron deficiency in frequent apheresis donors. Methods: Using a generalized linear mixed model (GLMM), a 180-day follow-up was conducted on 261 eligible apheresis donors at the Guangzhou Blood Center from January to July 2024. Hemoglobin (Hb), serum ferritin (SF), unsaturated iron-binding capacity (UIBC), total iron-binding capacity (TIBC), and transferrin saturation (TS) were selected as outcome variables. The effects of gender, age group, and number of donations within 180 days on these outcomes were analyzed and modeled. A general linear model (GLM) with repeated measures was applied to 55 donors who received health education interventions, comparing changes in Hb and iron metabolism-related indicators before and after follow-up and health education. Results: No significant difference in Hb levels was observed between first-time and regular apheresis donors, but SF levels were significantly higher in first-time donors (F=6.195, P<0.05). The GLMM revealed that female donors exhibited more significant reductions in Hb (T=-12.546) and SF (T=-5.829)(P<0.05 for both). Age group showed no interactive effects on Hb or SF changes. While number of donations within 180 days had no interactive effect on Hb, SF levels significantly decreased with increased number of donations (using ≥9 donations as the reference group; P<0.05 for all groups). After health education, Hb levels remained unchanged, but SF increased compared to pre-intervention levels (mean difference: -18.571, P<0.05), though a declining trend persisted compared to baseline (mean difference from baseline to post-intervention: 23.068,P<0.05). Conclusion: Female and number of donations are primary factors contributing to SF reduction in apheresis donors. Health education interventions promote SF recovery. Extending donation intervals and reinforcing iron deficiency-related health education may improve iron status in donors.
