Distribution characteristics of IgA in Zhuang blood donors and its influence on blood transfusion safety in Nanning

Qiuhong MO; Yang CHEN; Mingshuang LAI; Huihui MO; Baoren HE; Baojia HUANG; Yanya TANG; Linbin HUANG; Limin CHEN

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Distribution characteristics of IgA in Zhuang blood donors and its influence on blood transfusion safety in Nanning

VernacularTitle:南宁地区壮族献血人群IgA含量分布特征及对输血安全影响初探
Author: Qiuhong MO ¹ ; Yang CHEN ² ; Mingshuang LAI ¹ ; Huihui MO ¹ ; Baoren HE ¹ ; Baojia HUANG ¹ ; Yanya TANG ³ ; Linbin HUANG ¹ ; Limin CHEN ^{1
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Author Information

1. Naning Blood Center, Naning 530003, China
2. Nanning Health Talent and Technical Service Center, Nanning 530012, China
3. Mashan RAAS Apheresis Plasma Co., Ltd, Nanning 530600, China
4. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu 610052, China
Publication Type:Journal Article
Keywords: Zhuang blood donors; IgA deficiency; frequency; transfusion safety
From: Chinese Journal of Blood Transfusion 2025;38(6):811-816
CountryChina
Language:Chinese
Abstract: Objective: To analyze the distribution characteristics of immunoglobulin A (IgA) concentration in Nanning Zhuang blood donors by measuring the concentration of plasma IgA. Methods: Enzyme-linked immunosorbent assay (ELISA) was performed to measure the absorbance of 2 000 plasma samples from Zhuang blood donors. The IgA concentration in samples was calculated using the ELISA Calc regression/fitting technology program. Results: The standard curve demonstrated that ELISA detection of plasma IgA concentration exhibited good precision. The frequency of IgA deficiency was 0/2 000. No statistically significant difference in the distribution of IgA concentration was observed between males and females (P>0.05). The distribution of IgA concentration varied significantly across age groups: younger individuals (18-39 years old) had lower plasma IgA levels (mg/dL) compared to older individuals (40-56 years old): 5-89.99 mg/dL group, 8.80% (176/2 000) vs 17.20% (344/2 000); 90-450 mg/dL group,20.65% (413/2 000) vs 51.20% (1 024/2 000); >450 mg/dL group, 0.45%, (9/2 000) vs 1.70% (34/2 000), P<0.05. No significant difference in IgA concentration was found among different ABO blood types in Zhuang blood donors (P>0.05). Spearman correlation analysis revealed a positive correlation between age and IgA concentration (R =0.114, P<0.05). Conclusion: No individuals with IgA deficiency were screened out among the Zhuang blood donors in Nanning area, and plasma IgA levels progressively increase with age.